Deciding to Enroll in the Sickle Cell Clinical Trial

Reasons Rise Up Might Be a Good Fit

Eligibility criteria:

• You're 16 years of age or older
• You're diagnosed with sickle cell
• If you or your partner are capable of becoming pregnant, you must agree to use 2 forms of contraception
• You've had at least 2 but no more than 10 pain crises in the past year
  • Defined as pain requiring medical attention and treatment caused by acute chest syndrome, sustained erection, or red blood cell blockages in the liver, spleen, or elsewhere in the body
• You have a hemoglobin level between 5.5 and 10.5 g/dL
• If you are taking hydroxyurea, your hydroxyurea dose must stay the same for at least 90 days before starting this study drug

Reasons Rise Up Might Not Be a Good Fit

• If you're pregnant or breastfeeding
• If you're receiving regularly scheduled transfusions
• If you have any hepatobiliary disorders, including liver or gallbladder disease
• If you have severe kidney disease
• If you've undergone gene therapy or had a prior bone marrow or stem cell transplant
• If you're currently receiving treatment for sickle cell disease (such as voxelotor, crizanlizumab, or L-glutamine), with the exception of hydroxyurea
• If you're currently receiving therapies that stimulate blood production, such as erythropoietin